The superbug series: Part 2. The second of a three part series talks about antibiotic resistance showed by disease causing bacteria, its reasons, the problems associated with antibiotic resistance and the severity of the issue in India.

Researchers from the Indian Institute of Science, Bangalore use a computational approach to design peptides which are highly effective in killing drug resistant microbes.

A new study conducted by Pallavi Sinha and group from Institute of Medical Sciences, Banaras Hindu University and Boston Medical Centre has concluded that behavioral factors, like alcohol consumption and smoking, and clinical factors, like previous anti tubercular treatment, increases the risk of multi-drug resistant TB (MDR-TB).

Cancer is a difficult disease, both for patients and doctors. One of the many side effects of cancer therapies is secondary infections that are caused by a weakened immune system. Current strategies for treating bacterial infections in cancer patients have many drawbacks. Addressing these issues scientists from the Indian Institute of Technology, Delhi show that administering antimicrobial medicines with gold nanoparticles increases their efficacy by upto 40%.

Foodborne diseases, caused by Salmonella, are responsible for 1 in 10 illnesses globally. Treating Salmonella infections using traditional antibiotics is turning to be a challenge because of the development of drug resistant strains. Now, a new study at IISc has developed nanotechnology based nanocarries using silica that can deliver very small dosage of antibiotics to the affected cells, thus hitting the right target. Using laboratory experiments, the researchers found that these nanocarries performed much better than conventional antibiotics in all stages of the infection. The design of these nanocarries are generic, and can be used for delivering different antibiotics, they claim.